《冷血》（英文：In Cold Blood）是美国作家楚门·卡波特于1966出版的小说，详述1959年一起位于堪萨斯州霍尔库姆，优渥农人赫伯特·克拉特一家遭灭门的残暴凶杀案。卡波特获悉此事后，与好友作家哈波·李决定一同前往当地进行调查。他们访问了当地居民与该案的调查人员，摘记了上千页的纪录。凶手狄克与贝利在犯案后不久被逮捕，卡波特随后耗尽六年心血著成此书。《冷血》被公认是非虚构小说鼻祖及新新闻主义先驱，同时也成了卡波特的经典代表作之一。

Controversial and compelling, In Cold Blood reconstructs the murder in 1959 of a Kansas farmer, his wife and both their children. Truman Capote's comprehensive study of the killings and subsequent investigation explores the circumstances surrounding this terrible crime and the effect it had on those involved. At the centre of his study are the amoral young killers Perry Smith and Dick Hickcock, who, vividly drawn by Capote, are shown to be reprehensible yet entirely and frighteningly human.

The book that made Capote's name, In Cold Blood is a seminal work of modern prose, a remarkable synthesis of journalistic skill and powerfully evocative narrative.