Eisenstein's best-known work is The Printing Press as an Agent of Change, a two-volume, 750-page exploration of the effects of movable type printing on the literate elite of post-Gutenberg Western Europe. In this work she focuses on the printing press's functions of dissemination, standardization, and preservation and the way these functions aided the progress of the Protestant Reformation, the Renaissance, and the Scientific Revolution. Eisenstein's work brought historical method, rigor, and clarity to earlier ideas of Marshall McLuhan and others, about the general social effects of such media transitions.

This work provoked debate in the academic community from the moment it was published[4] and is still inspiring conversation and new research today.[5] Her work also influenced later thinking about the subsequent development of digital media. Her work on the transition from manuscript to print influenced thought about new transitions of print text to digital formats, including multimedia and new ideas about the definition of text.[6]

Elizabeth Lewisohn Eisenstein is an American historian of the French Revolution and early 19th century France. She is well-known for her work on the history of early printing, writing on the transition in media between the era of 'manuscript culture' and that of 'print culture', as well as the role of the printing press in effecting broad cultural change in Western civilization.